Early inhalant allergen sensitization at component level: an analysis in atopic Dutch children

Background Allergic rhinitis is a common respiratory disease in children and sensitization to inhalant allergens plays significant role its development. However, limited knowledge exists regarding profiles of allergen components atopic children, particularly the very young individuals. Understanding these could provide insights into early development allergic rhinitis. The objective this cross-sectional retrospective study was evaluate IgE-sensitization multiple their clinical relevance Dutch with specific focus on under age 4 years. Methods A total 243 were included analyzed using multiplex microarray analysis (ISAC). Clinical information obtained from records pediatric allergy outpatient clinic between 2011 2020. Specific IgE responses inhalation five sources (grass pollen, tree house dust mite, cat dog), examined. encompassed different groups compared those without symptoms. Results results demonstrated that present 92% cohort. Sensitization already evident at (87%), including infancy, rapid increase prevalence after 1 year age. House mite emerged as most predominant sensitizing childhood, followed by pollen later patterns similar symptomatic asymptomatic although exhibited higher frequencies values. comparable across all groups. Conclusion These findings highlight presence onset before 4, children. Notable molecules years include Bet v 1, Fel d Der f p 10 Phl being among infants. Moreover, cohort surpassed general European populations, emphasizing importance assessment management